Search results for " nutrigenomics"

showing 3 items of 3 documents

Obesity and Cardiometabolic Risk Factors : from Childhood to Adulthood

2021

Obesity has become a major epidemic in the 21st century. It increases the risk of dyslipidemia, hypertension, and type 2 diabetes, which are known cardiometabolic risk factors and components of the metabolic syndrome. Although overt cardiovascular (CV) diseases such as stroke or myocardial infarction are the domain of adulthood, it is evident that the CV continuum begins very early in life. Recognition of risk factors and early stages of CV damage, at a time when these processes are still reversible, and the development of prevention strategies are major pillars in reducing CV morbidity and mortality in the general population. In this review, we will discuss the role of well-known but also …

EpigenomicsMaleGerontologyPediatric ObesityobesityInfants Alimentacióobesity ; cardiometabolic risk factors ; hypertension ; dyslipidemia ; tracking phenomenon ; nutrigenomicsReviewType 2 diabetesnutrigenomicPregnancytracking phenomenon.TX341-641ChildPrenatal Nutritional Physiological PhenomenaMetabolic Syndromeeducation.field_of_studyNutrition and Dieteticscardiometabolic risk factorNutrigenomicsCardiorespiratory FitnessCardiovascular DiseasesChild PreschoolObesitatFemaleAdulttracking phenomenonhypertensionAdolescentPopulationChildhood obesityYoung AdultnutrigenomicsmedicineMortalitatHumansAdultseducationbusiness.industryNutrition. Foods and food supplydyslipidemiaInfant NewbornInfantCardiorespiratory fitnessmedicine.diseaseObesitycardiometabolic risk factorsDietMetabolic syndromebusinessDyslipidemiaFood Science
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Alcoholic Beverage and Meal Choices for the Prevention of Noncommunicable Diseases: A Randomized Nutrigenomic Trial

2018

Background. Noncommunicable diseases (NCDs) are the first cause of death worldwide. Mediterranean diet may play a crucial role in the prevention of NCDs, and the presence of wine in this diet could play a positive role on health. Methods. 54 healthy volunteers consumed one of the following beverages: red (RW) or white wine (WW), vodka (VDK), and/or Mediterranean meal (MeDM) and high-fat meal (HFM). Results. OxLDL-C changed significantly between baseline versus HFM, MeDM versus HFM, and HFM versus HFM + RW (p<0.05). Significant upregulation of catalase (CAT) was observed only after RW. Conversely, WW, VDK, RW + MeDM, HF + WW, and HF + VDK determined a significant downregulation of CAT gen…

Male0301 basic medicineAgingGPX1AntioxidantMediterranean dietmedicine.medical_treatmentWineMediterranean030204 cardiovascular system & hematologyDiet Mediterraneanmedicine.disease_causeBiochemistryAntioxidantsNutrigenomicsGlutathione Peroxidase GPX10302 clinical medicineSettore MED/49 - Scienze Tecniche Dietetiche Applicatechemistry.chemical_classificationMeallcsh:CytologyAlcoholic BeveragesGlutathione peroxidaseGeneral MedicineMiddle AgedCatalaseLipoproteins LDLAdolescent; Adult; Aged; Antioxidants; Catalase; Diet High-Fat; Diet Mediterranean; Ethanol; Female; Glutathione Peroxidase; Humans; Lipoproteins LDL; Male; Middle Aged; Noncommunicable Diseases; Nutrigenomics; Oxidative Stress; Superoxide Dismutase; Young Adult; Alcoholic Beverages; Wine; Biochemistry; Aging; Cell BiologyFemaleResearch ArticleAdultmedicine.medical_specialtyAdolescentArticle SubjectLipoproteinsSOD2Diet High-FatLDLYoung Adult03 medical and health sciencesInternal medicinemedicineHumanslcsh:QH573-671Noncommunicable DiseasesAgedGlutathione PeroxidaseEthanolSuperoxide Dismutasebusiness.industryCell BiologyDietHigh-FatOxidative Stress030104 developmental biologyEndocrinologychemistryWhite WinebusinessOxidative stressOxidative Medicine and Cellular Longevity
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Nutritional epigenomic and DNA-damage modulation effect of natural stilbenoids

2023

The aim of the present work is the evaluation of biological effects of natural stilbenoids found in Vitis vinifera, with a focus on their activity as epigenetic modulators. In the present study, resveratrol, pterostilbene and for the first time their dimers (±)-trans-δ-viniferin, (±)-trans-pterostilbene dehydrodimer were evaluated in Caco-2 and HepG-2 cell lines as potential epigenetic modulators. Stilbenoids were added in a Caco-2 cell culture as a model of the intestinal epithelial barrier and in the HepG-2 as a model of hepatic environment, to verify their dose-dependent toxicity, ability to interact with DNA, and epigenomic action. Resveratrol, pterostilbene, and (±)-trans-pterostilbene…

Settore BIO/18 - Geneticastilbenoids nutrigenomics resveratrol pterostilbene (±)-trans-δ-viniferin (±)-trans-pterostilbene dehydrodimer Caco-2 cells HepG-2 cells DNA methylation.Settore CHIM/10 - Chimica degli Alimenti
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